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Scientists at St. Jude Children's Research Hospital have shown that specific brain cells respond differently to H3.3 K27M, a mutation in the histone H3.3 protein that drives many cases of diffuse midline glioma (DMG), depending on the cells' location in the developing brain. Thes

Vaccines that turn the body’s immune system against tumors have shown promise in clinical trials, and a handful have been FDA approved for certain cancers. In many patients, however, these vaccines don’t stimulate enough of a response, and the approach some researchers have taken